| V/T | Voltage/Temperature |
| V&V | Verification and Validation |
| V | Volts |
| V3 | Virtual System Design Environment (GSFC) |
| VA | Validation Authority |
| VAAC | Volcanic Ash Advisory Center |
| VAC | Variance at Completion |
| VAGL | Vendor-Allocated Ground Latency |
| Val | Validation |
| VAT | Vendor Acceptance Testing |
| VBO | Vacuum Bake Out |
| VC | Visually Clean |
| VC | Virtual Channel |
| VCDU | virtual channel data unit |
| VCI | Vegetation Condition Index |
| VCID | Virtual Channel ID |
| VCRM | Validation Cross Reference Matrix |
| Vdc | Volts-Direct Current |
| VDD | Version Description Document |
| VDR | Verification Design Review |
| VFCLD | Variable Fire with CLouDs |
| VFD | Variable Frequency Drive |
| VFM | Vertical Feature Mask |
| VFNOCLD | Variable Fire NO CLouDs |
| VHDL | Virtual Hardware Description Language |
| VHF | Very High Frequency |
| VIF | Vertical Integration Facility |
| VII | Visual Information Initiative |
| VIIRS | Visible Infrared Imaging Radiometer Suite (Suomi NPP satellite) |
| VIMF | Virtual Instrument Mounting Frame |
| VIS | Visible |
| VISIT | Virtual Institute for Satellite Integration Training |
| VISSR | Visible/Infrared Spin Scan-Radiometer |
| VLAN | Virtual LAN |
| VLF | Very Low Frequency |
| VM | Virtual Machine |
| VMF | Virtual Mounting Frame |
| VNC | Virtual Network Computing |
| VNIR | Visible Near-Infrared |
| VO | Validation/Verification Objectives |
| VOB | Versioned Object Base |
| VoIP | Voice Over Internet Protocol |
| VOSB | Veteran Owned Small Business |
| VP | Vice President |
| VPC | Virtual Port Channel |
| VPN | Virtual Private Network |
| VPOL | Vertical Polarization |
| VR1 | Class 1 Variance |
| VR2 | Class 2 Variance |
| VRF | Virtual Routing and Forwarding |
| VRQ | Hardware Qualification Variance |
| VSCS | Voice Shifting and Control System |
| VSDE | Virtual System Design Environment |
| VSWR | Voltage Standing Wave Radio |
| VTL | Verification Tracking Log |
| VVP | Verification and Validation Plan |
| VXR | Visible/Near Infrared Transfer Radiometer |